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记录在蟾蜍二烯羟酸内酯（bufadienolides）、甾体酶学与生物催化反应预测方向上的文献深度剖析。遵循严格证据溯源，每周四固定更新一篇。
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Phytochemical investigation of Bufo bufo gargarizans skin yielded two new lactam-bearing bufadienolides alongside 22 known analogs. In vitro evaluation revealed differential cytotoxicity across human cancer cell lines, demonstrating the influence of C3 nitrogenous substitutions on antiproliferative activity.
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| 发布计划时间 | 论文题录 | 期刊 |
|---|---|---|
| 2026-11-05 09:00 | Synthesis of Bufadienolide Natural Products and Analogs via Singlet Oxygen Oxidation and Late-Stage Modification DOI: 10.1021/acs.joc.6c00124 |
The Journal of Organic Chemistry |
| 2026-11-12 09:00 | Functional characterization of 3β-hydroxysteroid dehydrogenases in Asiatic toad reveals an efficient broad substrate specificity of Bg-3βHSD2 DOI: 10.1042/bsr20260032 |
Bioscience Reports |
| 2026-11-19 09:00 | Mammalian-like steroidogenesis in plants gives rise to endocrine-mimetic cardenolides DOI: 10.1126/sciadv.aeb5460 |
Science Advances |
| 2026-11-26 09:00 | Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids DOI: 10.1038/s41467-025-58926-9 |
Nature Communications |
| 2026-12-03 09:00 | Divergent evolution of fungal P450 monooxygenase unlocks simultaneous access to C12β and C15α oxyfunctionalization of steroids DOI: 10.1038/s41467-025-65736-6 |
Nature Communications |
| 2026-12-10 09:00 | Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria DOI: 10.1038/s41467-025-67278-3 |
Nature Communications |
| 2026-12-17 09:00 | Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids DOI: 10.1038/s41467-026-69211-8 |
Nature Communications |
| 2026-12-24 09:00 | Connecting chemical and protein sequence space to predict biocatalytic reactions DOI: 10.1038/s41586-025-09519-5 |
Nature |
| 2026-12-31 09:00 | Graph-sequence enhanced transformer for template-free prediction of natural product biosynthesis DOI: 10.1016/j.patter.2025.101259 |
Patterns |