Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity
Abstract & Summary
Phytochemical investigation of Bufo bufo gargarizans skin yielded two new lactam-bearing bufadienolides alongside 22 known analogs. In vitro evaluation revealed differential cytotoxicity across human cancer cell lines, demonstrating the influence of C3 nitrogenous substitutions on antiproliferative activity.
Full detailed literature review and mechanism breakdown is published in Chinese: /notes/bufadienolides-diversity-bufo-bufo.html
Cite this paper
@article{meng2024bufadienolides,
title = {Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity},
author = {Lingjie Meng and Qian Cao and Xinyi Du and Huijing Lv and Chengjin Li and Xiaoke Zhang and Nian Jiang and Yi Xiao},
journal = {Scientific Reports},
year = {2024},
doi = {10.1038/s41598-024-79194-5},
url = {https://doi.org/10.1038/s41598-024-79194-5}
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