Synthesis of Bufadienolide Natural Products and Analogs via Singlet Oxygen Oxidation and Late-Stage Modification
Abstract & Summary
A unified synthetic route to bufadienolide natural products and analogs was established using singlet oxygen [4+2] cycloaddition to construct the α-pyrone ring. Divergent late-stage functionalization enabled scalable access to cinobufotalin, bufotalin, and targeted structural variants for structure-activity exploration.
Full detailed literature review and mechanism breakdown is published in Chinese: /notes/bufadienolide-singlet-oxygen-synthesis.html
Cite this paper
@article{tichvon2026bufadienolide,
title = {Synthesis of Bufadienolide Natural Products and Analogs via Singlet Oxygen Oxidation and Late-Stage Modification},
author = {Colin Tichvon and Nasma Ibrahim and Kevin Kong and Pavel Nagorny},
journal = {The Journal of Organic Chemistry},
year = {2026},
doi = {10.1021/acs.joc.6c00124},
url = {https://doi.org/10.1021/acs.joc.6c00124}
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